Analytical Chemistry & Bioanalysis Services

CanAm is staffed with a trained and experienced PhD analytical chemist and is equipped with proper analytical instruments to be able to offer services in analytical chemistry and bioanalysis, such as:

Analytical Chemistry

  • HPLC-UV analysis

  • LC-MS analysis

  • Determination of chemical purity

  • Certificates of Analysis

  • Synthetic impurity identification and structure elucidation

Solubility Testing

Solubility determination in solvents, buffers, or vehicles

Stability Studies

  • Stability at various pH's

  • Thermal stability

  • Photochemical stability

Pharmacokinetics

LC-MS/MS units dedicated to ADME analysis

  • Blood levels and plasma levels

  • Bioavailability in rat, mouse, and dog

  • Mouse PK with up to 10 time points per animal (10 µL sampling)

  • Liver microsome incubations

  • Analysis of biological samples by LC-MS/MS

Biological Services

  • Provide integrated biological services to rapidly determine the biological activity and properties of client’s synthesized compounds

  • Possess the infrastructure and experience to run biochemical assays such as ELISA to determine compound interaction with client target

  • ELISA assay development is available

  • Perform metabolic stability testing of client compounds using animal or human liver microsomes

  • Coordinate in-vivo animal testing for pharmacokinetic and distribution studies and perform analytic support using a method developed in parallel with the animal testing to provide a rapid turn-around-time

Analytical Chemistry Expertise

CanAm Bioresearch has a high level of skill in analytical chemistry not only because of its connection with synthetic organic chemistry, but also because it has equipment and experience in bioanalysis such as plasma level analysis and blood level analysis from tissue distribution studies. Pharmacokinetics profiles including rat PK, mouse PK and dose-exposure level relationships are also part of our services. Using our LC-MS and HPLC-UV, we have the ability to perform the majority of first-line ADME analyses.

In combination with our multinuclear NMR, we can also elucidate the structure of metabolites and prove them by total synthesis if needed. Our services are orientated towards the fast pace of discovery, and we pride ourselves in producing PK results in only a few days from receipt of the samples. Due to our fast pace, we specialize in non-GLP work.

CanAm Bioresearch has also performed analyses for the determination of percentage purity of chemicals, in the form of certificates of analysis. We also have contributed analytical services to help monitor processes in the agrochemical area, and in the optimization of chemical processes where monitoring trace impurities and side-products is essential. In this context, our LC-MS has delivered key impurity profiles for chemical processes.